Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell Non-Hodgkin’s Lymphoma: Results of the FAB/LMB 96 international study
Identifieur interne : 000347 ( Main/Exploration ); précédent : 000346; suivant : 000348Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell Non-Hodgkin’s Lymphoma: Results of the FAB/LMB 96 international study
Auteurs : Ha Poirel [France, Belgique] ; Ms Cairo [États-Unis] ; Na Heerema ; J. Swansbury [Royaume-Uni] ; A. Aupérin [France] ; E. Launay [France] ; Wg Sanger ; P. Talley [Royaume-Uni] ; Sl Perkins [États-Unis] ; M. Raphaël [France] ; K. Mccarthy [Royaume-Uni] ; R. Sposto [États-Unis] ; M. Gerrard [Royaume-Uni] ; A. Bernheim [France] ; C. Patte [France]Source :
- Leukemia [ 0887-6924 ] ; 2008.
Abstract
Clinical studies showed that advanced stage, high LDH, poor response to reduction therapy and combined bone marrow and central nervous system disease are significantly associated with a decreased event free survival (EFS) in pediatric mature B-NHL treated on FAB/LMB96. Although rearranged MYC/8q24 (R8q24) is characteristic of Burkitt Lymphoma (BL), little information is available on other cytogenetic abnormalities and their prognostic importance. We performed an international review of 238 abnormal karyotypes in childhood mature-B-NHL treated on FAB/LMB96: 76% BL, 8% Burkitt-like lymphoma, 13% diffuse large B-cell lymphoma (DLBCL). The main BL R8q24 associated chromosomal aberrations were +1q [29%], +7q and del(13q) [14% each]. The DLBCL appeared heterogeneous and more complex. Incidence of R8q24 [34%] was higher than reported in adult DLBCL. The prognostic value of cytogenetic abnormalities on EFS was studied by Cox model controlling for the known risk factors: R8q24, +7q and del(13q) were independently associated with a significant inferior EFS [HR: 6.1 (p=0.030), 2.5 (p=0.015), 4.0 (p=0.0003), respectively]. The adverse prognosis of R8q24 was observed only in DLBCL while del(13q) and +7q had a similar effect in DLBCL and BL. These results emphasize the significant biological heterogeneity and the development of cytogenetic risk adapted therapy in childhood mature-B-NHL.
Url:
DOI: 10.1038/leu.2008.312
PubMed: 19020548
PubMed Central: 2988438
Affiliations:
- Belgique, France, Royaume-Uni, États-Unis
- Californie, Région de Bruxelles-Capitale, Utah, État de New York, Île-de-France
- Bobigny, Bruxelles, Los Angeles, New York
- Université Columbia, Université Paris 13, Université de Californie du Sud
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell Non-Hodgkin’s Lymphoma: Results of the FAB/LMB 96 international study</title><author><name sortKey="Poirel, Ha" sort="Poirel, Ha" uniqKey="Poirel H" first="Ha" last="Poirel">Ha Poirel</name><affiliation wicri:level="4"><nlm:aff id="A1">Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName><orgName type="university">Université Paris 13</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Cliniques Universitaire Saint-Luc UCL & de Duve Institute, Hematological Genetics & Human Molecular Genetics (GEHU), Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques Universitaire Saint-Luc UCL & de Duve Institute, Hematological Genetics & Human Molecular Genetics (GEHU), Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Cairo, Ms" sort="Cairo, Ms" uniqKey="Cairo M" first="Ms" last="Cairo">Ms Cairo</name><affiliation wicri:level="4"><nlm:aff id="A3">Division of Pediatric Blood and Marrow Transplantation, Morgan Stanley Children’s Hospital of New York Presbyterian, Columbia University, New York, NY-USA</nlm:aff><orgName type="university">Université Columbia</orgName><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Heerema, Na" sort="Heerema, Na" uniqKey="Heerema N" first="Na" last="Heerema">Na Heerema</name><affiliation><nlm:aff id="A4">Department of Pathology - Cytogenetics, The Ohio State University, Columbus, OH-USA</nlm:aff><wicri:noCountry code="subfield">OH-USA</wicri:noCountry></affiliation></author><author><name sortKey="Swansbury, J" sort="Swansbury, J" uniqKey="Swansbury J" first="J" last="Swansbury">J. Swansbury</name><affiliation wicri:level="1"><nlm:aff id="A5">Haematology Cytogenetics, The Royal Marsden Hospital, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematology Cytogenetics, The Royal Marsden Hospital, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Auperin, A" sort="Auperin, A" uniqKey="Auperin A" first="A" last="Aupérin">A. Aupérin</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Biostatistics, Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Launay, E" sort="Launay, E" uniqKey="Launay E" first="E" last="Launay">E. Launay</name><affiliation wicri:level="4"><nlm:aff id="A1">Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName><orgName type="university">Université Paris 13</orgName></affiliation></author><author><name sortKey="Sanger, Wg" sort="Sanger, Wg" uniqKey="Sanger W" first="Wg" last="Sanger">Wg Sanger</name><affiliation><nlm:aff id="A7">Human Genetics Laboratory, University of Nebraska Medical Center, Omaha, NE-USA</nlm:aff><wicri:noCountry code="subfield">NE-USA</wicri:noCountry></affiliation></author><author><name sortKey="Talley, P" sort="Talley, P" uniqKey="Talley P" first="P" last="Talley">P. Talley</name><affiliation wicri:level="1"><nlm:aff id="A8">Cytogenetics, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cytogenetics, Sheffield Children’s Hospital, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Perkins, Sl" sort="Perkins, Sl" uniqKey="Perkins S" first="Sl" last="Perkins">Sl Perkins</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Raphael, M" sort="Raphael, M" uniqKey="Raphael M" first="M" last="Raphaël">M. Raphaël</name><affiliation wicri:level="4"><nlm:aff id="A1">Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName><orgName type="university">Université Paris 13</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Biological Hematology, CHU Bicêtre –Assistance Publique-Hôpitaux de Paris, INSERM U802, Université Paris-Sud 11, Le Kremlin-Bicêtre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Bicêtre –Assistance Publique-Hôpitaux de Paris, INSERM U802, Université Paris-Sud 11, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, K" sort="Mccarthy, K" uniqKey="Mccarthy K" first="K" last="Mccarthy">K. Mccarthy</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, Gloucestershire Hospitals, NHS Foundation, Gloucestershire, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, Gloucestershire Hospitals, NHS Foundation, Gloucestershire</wicri:regionArea><wicri:noRegion>Gloucestershire</wicri:noRegion></affiliation></author><author><name sortKey="Sposto, R" sort="Sposto, R" uniqKey="Sposto R" first="R" last="Sposto">R. Sposto</name><affiliation wicri:level="4"><nlm:aff id="A12">Department of Biostatistics, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA-USA</nlm:aff><orgName type="university">Université de Californie du Sud</orgName><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gerrard, M" sort="Gerrard, M" uniqKey="Gerrard M" first="M" last="Gerrard">M. Gerrard</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Paediatric Oncology, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatric Oncology, Sheffield Children’s Hospital, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Bernheim, A" sort="Bernheim, A" uniqKey="Bernheim A" first="A" last="Bernheim">A. Bernheim</name><affiliation wicri:level="1"><nlm:aff id="A14">Laboratoire de genomique cellulaire des cancers, Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de genomique cellulaire des cancers, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Patte, C" sort="Patte, C" uniqKey="Patte C" first="C" last="Patte">C. Patte</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Pediatric onco-hematology, Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pediatric onco-hematology, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19020548</idno><idno type="pmc">2988438</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988438</idno><idno type="RBID">PMC:2988438</idno><idno type="doi">10.1038/leu.2008.312</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000217</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000217</idno><idno type="wicri:Area/Pmc/Curation">000217</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000217</idno><idno type="wicri:Area/Pmc/Checkpoint">000030</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000030</idno><idno type="wicri:Area/Ncbi/Merge">000038</idno><idno type="wicri:Area/Ncbi/Curation">000038</idno><idno type="wicri:Area/Ncbi/Checkpoint">000038</idno><idno type="wicri:doubleKey">0887-6924:2008:Poirel H:specific:cytogenetic:abnormalities</idno><idno type="wicri:Area/Main/Merge">000351</idno><idno type="wicri:Area/Main/Curation">000347</idno><idno type="wicri:Area/Main/Exploration">000347</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell Non-Hodgkin’s Lymphoma: Results of the FAB/LMB 96 international study</title><author><name sortKey="Poirel, Ha" sort="Poirel, Ha" uniqKey="Poirel H" first="Ha" last="Poirel">Ha Poirel</name><affiliation wicri:level="4"><nlm:aff id="A1">Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName><orgName type="university">Université Paris 13</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Cliniques Universitaire Saint-Luc UCL & de Duve Institute, Hematological Genetics & Human Molecular Genetics (GEHU), Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques Universitaire Saint-Luc UCL & de Duve Institute, Hematological Genetics & Human Molecular Genetics (GEHU), Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Cairo, Ms" sort="Cairo, Ms" uniqKey="Cairo M" first="Ms" last="Cairo">Ms Cairo</name><affiliation wicri:level="4"><nlm:aff id="A3">Division of Pediatric Blood and Marrow Transplantation, Morgan Stanley Children’s Hospital of New York Presbyterian, Columbia University, New York, NY-USA</nlm:aff><orgName type="university">Université Columbia</orgName><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Heerema, Na" sort="Heerema, Na" uniqKey="Heerema N" first="Na" last="Heerema">Na Heerema</name><affiliation><nlm:aff id="A4">Department of Pathology - Cytogenetics, The Ohio State University, Columbus, OH-USA</nlm:aff><wicri:noCountry code="subfield">OH-USA</wicri:noCountry></affiliation></author><author><name sortKey="Swansbury, J" sort="Swansbury, J" uniqKey="Swansbury J" first="J" last="Swansbury">J. Swansbury</name><affiliation wicri:level="1"><nlm:aff id="A5">Haematology Cytogenetics, The Royal Marsden Hospital, Sutton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Haematology Cytogenetics, The Royal Marsden Hospital, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Auperin, A" sort="Auperin, A" uniqKey="Auperin A" first="A" last="Aupérin">A. Aupérin</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Biostatistics, Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Launay, E" sort="Launay, E" uniqKey="Launay E" first="E" last="Launay">E. Launay</name><affiliation wicri:level="4"><nlm:aff id="A1">Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName><orgName type="university">Université Paris 13</orgName></affiliation></author><author><name sortKey="Sanger, Wg" sort="Sanger, Wg" uniqKey="Sanger W" first="Wg" last="Sanger">Wg Sanger</name><affiliation><nlm:aff id="A7">Human Genetics Laboratory, University of Nebraska Medical Center, Omaha, NE-USA</nlm:aff><wicri:noCountry code="subfield">NE-USA</wicri:noCountry></affiliation></author><author><name sortKey="Talley, P" sort="Talley, P" uniqKey="Talley P" first="P" last="Talley">P. Talley</name><affiliation wicri:level="1"><nlm:aff id="A8">Cytogenetics, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cytogenetics, Sheffield Children’s Hospital, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Perkins, Sl" sort="Perkins, Sl" uniqKey="Perkins S" first="Sl" last="Perkins">Sl Perkins</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Raphael, M" sort="Raphael, M" uniqKey="Raphael M" first="M" last="Raphaël">M. Raphaël</name><affiliation wicri:level="4"><nlm:aff id="A1">Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Avicenne – Université Paris 13, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName><orgName type="university">Université Paris 13</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A10">Biological Hematology, CHU Bicêtre –Assistance Publique-Hôpitaux de Paris, INSERM U802, Université Paris-Sud 11, Le Kremlin-Bicêtre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Biological Hematology, CHU Bicêtre –Assistance Publique-Hôpitaux de Paris, INSERM U802, Université Paris-Sud 11, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, K" sort="Mccarthy, K" uniqKey="Mccarthy K" first="K" last="Mccarthy">K. Mccarthy</name><affiliation wicri:level="1"><nlm:aff id="A11">Department of Pathology, Gloucestershire Hospitals, NHS Foundation, Gloucestershire, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, Gloucestershire Hospitals, NHS Foundation, Gloucestershire</wicri:regionArea><wicri:noRegion>Gloucestershire</wicri:noRegion></affiliation></author><author><name sortKey="Sposto, R" sort="Sposto, R" uniqKey="Sposto R" first="R" last="Sposto">R. Sposto</name><affiliation wicri:level="4"><nlm:aff id="A12">Department of Biostatistics, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA-USA</nlm:aff><orgName type="university">Université de Californie du Sud</orgName><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gerrard, M" sort="Gerrard, M" uniqKey="Gerrard M" first="M" last="Gerrard">M. Gerrard</name><affiliation wicri:level="1"><nlm:aff id="A13">Department of Paediatric Oncology, Sheffield Children’s Hospital, Sheffield, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Paediatric Oncology, Sheffield Children’s Hospital, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Bernheim, A" sort="Bernheim, A" uniqKey="Bernheim A" first="A" last="Bernheim">A. Bernheim</name><affiliation wicri:level="1"><nlm:aff id="A14">Laboratoire de genomique cellulaire des cancers, Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de genomique cellulaire des cancers, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Patte, C" sort="Patte, C" uniqKey="Patte C" first="C" last="Patte">C. Patte</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Pediatric onco-hematology, Institut Gustave Roussy, Villejuif, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Pediatric onco-hematology, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></analytic><series><title level="j">Leukemia</title><idno type="ISSN">0887-6924</idno><idno type="eISSN">1476-5551</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Clinical studies showed that advanced stage, high LDH, poor response to reduction therapy and combined bone marrow and central nervous system disease are significantly associated with a decreased event free survival (EFS) in pediatric mature B-NHL treated on FAB/LMB96. Although rearranged MYC/8q24 (R8q24) is characteristic of Burkitt Lymphoma (BL), little information is available on other cytogenetic abnormalities and their prognostic importance. We performed an international review of 238 abnormal karyotypes in childhood mature-B-NHL treated on FAB/LMB96: 76% BL, 8% Burkitt-like lymphoma, 13% diffuse large B-cell lymphoma (DLBCL). The main BL R8q24 associated chromosomal aberrations were +1q [29%], +7q and del(13q) [14% each]. The DLBCL appeared heterogeneous and more complex. Incidence of R8q24 [34%] was higher than reported in adult DLBCL. The prognostic value of cytogenetic abnormalities on EFS was studied by Cox model controlling for the known risk factors: R8q24, +7q and del(13q) were independently associated with a significant inferior EFS [HR: 6.1 (p=0.030), 2.5 (p=0.015), 4.0 (p=0.0003), respectively]. The adverse prognosis of R8q24 was observed only in DLBCL while del(13q) and +7q had a similar effect in DLBCL and BL. These results emphasize the significant biological heterogeneity and the development of cytogenetic risk adapted therapy in childhood mature-B-NHL.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Patte, C" uniqKey="Patte C">C Patte</name></author><author><name sortKey="Auperin, A" uniqKey="Auperin A">A Auperin</name></author><author><name sortKey="Gerrard, M" uniqKey="Gerrard M">M Gerrard</name></author><author><name sortKey="Michon, J" uniqKey="Michon J">J Michon</name></author><author><name sortKey="Pinkerson, Cr" uniqKey="Pinkerson C">CR Pinkerson</name></author><author><name sortKey="Sposto, R" uniqKey="Sposto R">R Sposto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairo, Ms" uniqKey="Cairo M">MS Cairo</name></author><author><name sortKey="Gerrard, M" uniqKey="Gerrard M">M Gerrard</name></author><author><name sortKey="Sposto, R" uniqKey="Sposto R">R Sposto</name></author><author><name sortKey="Auperin, A" uniqKey="Auperin A">A Auperin</name></author><author><name sortKey="Pinkerson, Cr" uniqKey="Pinkerson C">CR Pinkerson</name></author><author><name sortKey="Michon, J" uniqKey="Michon J">J Michon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerrard, M" uniqKey="Gerrard M">M Gerrard</name></author><author><name sortKey="Cairo, Ms" uniqKey="Cairo M">MS Cairo</name></author><author><name sortKey="Weston, C" uniqKey="Weston C">C Weston</name></author><author><name sortKey="Auperin, A" uniqKey="Auperin A">A Auperin</name></author><author><name sortKey="Pinkerton, R" uniqKey="Pinkerton R">R Pinkerton</name></author><author><name sortKey="Lambilliote, A" uniqKey="Lambilliote A">A Lambilliote</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, Nl" uniqKey="Harris N">NL Harris</name></author><author><name sortKey="Jaffe, Es" uniqKey="Jaffe E">ES Jaffe</name></author><author><name sortKey="Stein, 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uniqKey="Boerma E">EJ Boerma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawasaki, C" uniqKey="Kawasaki C">C Kawasaki</name></author><author><name sortKey="Ohshim, K" uniqKey="Ohshim K">K Ohshim</name></author><author><name sortKey="Suzumiya, J" uniqKey="Suzumiya J">J Suzumiya</name></author><author><name sortKey="Kanda, M" uniqKey="Kanda M">M Kanda</name></author><author><name sortKey="Tsuchiya, T" uniqKey="Tsuchiya T">T Tsuchiya</name></author><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akasaka, T" uniqKey="Akasaka T">T Akasaka</name></author><author><name sortKey="Akasaka, H" uniqKey="Akasaka H">H Akasaka</name></author><author><name sortKey="Ueda, C" uniqKey="Ueda C">C Ueda</name></author><author><name sortKey="Kanda, M" uniqKey="Kanda M">M Kanda</name></author><author><name sortKey="Tsuchiya, T" uniqKey="Tsuchiya T">T 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Krams</name></author><author><name sortKey="Wacker, Hh" uniqKey="Wacker H">HH Wacker</name></author><author><name sortKey="Burkhardt, B" uniqKey="Burkhardt B">B Burkhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenwald, A" uniqKey="Rosenwald A">A Rosenwald</name></author><author><name sortKey="Wright, G" uniqKey="Wright G">G Wright</name></author><author><name sortKey="Chan, Wc" uniqKey="Chan W">WC Chan</name></author><author><name sortKey="Connors, Jm" uniqKey="Connors J">JM Connors</name></author><author><name sortKey="Campo, E" uniqKey="Campo E">E Campo</name></author><author><name sortKey="Fisher, Ri" uniqKey="Fisher R">RI Fisher</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Région de Bruxelles-Capitale</li><li>Utah</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Bruxelles</li><li>Los Angeles</li><li>New York</li></settlement><orgName><li>Université Columbia</li><li>Université Paris 13</li><li>Université de Californie du Sud</li></orgName></list><tree><noCountry><name sortKey="Heerema, Na" sort="Heerema, Na" uniqKey="Heerema N" first="Na" last="Heerema">Na Heerema</name><name sortKey="Sanger, Wg" sort="Sanger, Wg" uniqKey="Sanger W" first="Wg" last="Sanger">Wg Sanger</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Poirel, Ha" sort="Poirel, Ha" uniqKey="Poirel H" first="Ha" last="Poirel">Ha Poirel</name></region><name sortKey="Auperin, A" sort="Auperin, A" uniqKey="Auperin A" first="A" last="Aupérin">A. Aupérin</name><name sortKey="Bernheim, A" sort="Bernheim, A" uniqKey="Bernheim A" first="A" last="Bernheim">A. Bernheim</name><name sortKey="Launay, E" sort="Launay, E" uniqKey="Launay E" first="E" last="Launay">E. Launay</name><name sortKey="Patte, C" sort="Patte, C" uniqKey="Patte C" first="C" last="Patte">C. Patte</name><name sortKey="Raphael, M" sort="Raphael, M" uniqKey="Raphael M" first="M" last="Raphaël">M. Raphaël</name><name sortKey="Raphael, M" sort="Raphael, M" uniqKey="Raphael M" first="M" last="Raphaël">M. Raphaël</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Poirel, Ha" sort="Poirel, Ha" uniqKey="Poirel H" first="Ha" last="Poirel">Ha Poirel</name></region></country><country name="États-Unis"><region name="État de New York"><name sortKey="Cairo, Ms" sort="Cairo, Ms" uniqKey="Cairo M" first="Ms" last="Cairo">Ms Cairo</name></region><name sortKey="Perkins, Sl" sort="Perkins, Sl" uniqKey="Perkins S" first="Sl" last="Perkins">Sl Perkins</name><name sortKey="Sposto, R" sort="Sposto, R" uniqKey="Sposto R" first="R" last="Sposto">R. Sposto</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Swansbury, J" sort="Swansbury, J" uniqKey="Swansbury J" first="J" last="Swansbury">J. Swansbury</name></noRegion><name sortKey="Gerrard, M" sort="Gerrard, M" uniqKey="Gerrard M" first="M" last="Gerrard">M. Gerrard</name><name sortKey="Mccarthy, K" sort="Mccarthy, K" uniqKey="Mccarthy K" first="K" last="Mccarthy">K. Mccarthy</name><name sortKey="Talley, P" sort="Talley, P" uniqKey="Talley P" first="P" last="Talley">P. Talley</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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